NAOI

Yes. "NAOI" is in the ENABLE word list, accepted by Words With Friends and most open Scrabble apps. It scores 4 points in Scrabble and 5 points in Words With Friends.

In Scrabble, "NAOI" is worth 4 points before bonuses. In Words With Friends, it's worth 5 points. Played on a triple-word-score, the Scrabble value becomes 12.

The inner part of a Greek temple. It contained a statue of the appropriate deity surrounded by a colonnaded portico and later gave rise to the Roman cella.

No, "NAOI" has no anagrams in the ENABLE dictionary — it's the only word that can be formed from its exact letters.