FIE

Yes. "FIE" is in the ENABLE word list, accepted by Words With Friends and most open Scrabble apps. It scores 6 points in Scrabble and 6 points in Words With Friends.

In Scrabble, "FIE" is worth 6 points before bonuses. In Words With Friends, it's worth 6 points. Played on a triple-word-score, the Scrabble value becomes 18.

Often followed by on or upon: used to express distaste, disgust, or outrage.

No, "FIE" has no anagrams in the ENABLE dictionary — it's the only word that can be formed from its exact letters.