DYKEY

Yes. "DYKEY" is in the ENABLE word list, accepted by Words With Friends and most open Scrabble apps. It scores 16 points in Scrabble and 14 points in Words With Friends.

In Scrabble, "DYKEY" is worth 16 points before bonuses. In Words With Friends, it's worth 14 points. Played on a triple-word-score, the Scrabble value becomes 48.

Of a woman, whether actually lesbian or not, having stereotypically lesbian characteristics; that looks like a dyke.

No, "DYKEY" has no anagrams in the ENABLE dictionary — it's the only word that can be formed from its exact letters.