ANOLE

Yes. "ANOLE" is in the ENABLE word list, accepted by Words With Friends and most open Scrabble apps. It scores 5 points in Scrabble and 7 points in Words With Friends.

In Scrabble, "ANOLE" is worth 5 points before bonuses. In Words With Friends, it's worth 7 points. Played on a triple-word-score, the Scrabble value becomes 15.

Any of the Anolis genus of arboreal American lizards (such as the American chameleon) from the iguana family which feature a brightly colored dewlap and color-changing ability.

1 anagram can be formed using the same letters as ANOLE: ALONE.